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Melatonin

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MELATONIN CENTRAL
The complete reference center and
information source for Melatonin.

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Caution on Melatonin this caution appeared at one time in Lifelines.com's library.

Melatonin & Aging  
It is one of the most potent antioxidants yet discovered, an immune booster, heart helper, and mood elevator.

Melatonin: A Chemical Slumber Switch  
Dr. Wurtman, professor of neuroscience and director of MIT's General Clinical Research Centcr (GCRC), has been exploring the hypnotic potential of melatonin since the mid-1980's, but his interest in this substance goes back even farther. Scientists have since uncovered a fascinating, but still poorly understood, relationship between melatonin, environmental lighting, and the regulation of the body's biological clock.

5-HTP / 5 Hydroxy L-Tryptophan / Tryptophan / Seratonin
Sleep Disorders. The chemical serotonin is important for a variety of brain functions. Its deficit is now believed to be central to the development of depression, agitation, sleep disorders, obesity and addiction. Serotonin can be produced in the body from the dietary amino acid tryptophan in only two steps. Serotonin can also be made from 5-hydroxy L-tryptophan (5-HTP) which is simply, the modified amino acid obtained from plant sources.

5HTP L-Tryptophan - The Product  
What does depression, insomnia, anxiety, suicide, migraines, PMS, obsessive/compulsive behavior, stress, obesity, and addiction have in common? All of these conditions are manifestations of low levels of serotonin. Now a natural and safe alternative to these drugs is available in the form of 5-Hydroxy L-Tryptophan (5-HTP). 5-HTP is ten times more active than L-tryptophan and is the immediate precursor to serotonin (5-Hydroxy tryptamine or 5-HT).

Cognitive Enhancement Research Institute  
Melatonin is under investigation as a treatment for a number of conditions, including jet-lag, seasonal affective disorder (SAD), depression, and cancer. Pineal polypeptide extract (which contains a broad spectrum of other, protein-based pineal hormones) has been shown to inhibit the development of atherosclerosis, reduce blood triglyceride levels, improve cellular immunity, and increase lifespan in animals.

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Melatonin / Patient Information - American Family Physician  
Melatonin can be used to treat insomnia (difficulty falling asleep and/or staying asleep). It can also be taken to prevent jet lag. Beyond that, there is little scientific evidence that melatonin has a role in promoting health or treating disease.

Yasir El-Sherif's Home Page  
This page is dedicated to research in melatonin Some of my interests include the effects of melatonin on the electrophysiology of the Central Nervous System (CNS). Technical information.

Nutrition Information on Melatonin for Insomnia and Sleep Disorders, Jet Lag.  
Health tips on your immune system not normally given by your health care provider. Nighttime melatonin levels are low in people with major depressive and panic disorders.

Melatonin Laboratory Findings
The goal of the Melatonin Breakout Group was to evaluate published data relative to its quality and consistency for possible EMF effects on melatonin production and its physiological and health related consequences.

Melatonin & Cancer
Melatonin vs Cancer - from The Cancer Chronicles #27 May 1995 by Ralph W. Moss, Ph.D.  Some cancer patients are now taking a hormonal supplement called melatonin as part of their comprehensive, non-toxic cancer treatment plan.

Melatonin Potentially Useful but Safety, Efficacy Remain Uncertain...
MELATONIN users are the unwitting subjects in a large-scale uncontrolled experiment, according to specialists in sleep and biological rhythms attending a workshop on melatonin and sleep at the National Institutes of Health (NIH) in Bethesda, Md, in August. The scientists urged the NIH to support a multicenter controlled clinical trial to determine melatonin's efficacy and long-term safety.

CNN - FDA can't assure safety of melatonin - Mar. 5,1996
WASHINGTON (CNN) -- The doses available in health food stores may boost levels of the hormone up to hundreds of times above normal. "There are reports of some people having depression, becoming much worse after taking melatonin. There are reports of people developing hallucinations, in particular hallucinatory dreams after taking melatonin," says Dr. Dan Oren, also from the mental health institute.

CNN investigation prompts nationwide recall. Melatonin tablets questioned
PASADENA, California (CNN) -- A CNN Medical Unit investigation of melatonin is prompting a distributor to issue a nationwide recall of tablets that contain only half as much melatonin as claimed. The hormone is usually used to help people sleep or fight jet lag, though some people claim it can also help prevent cancer or even delay aging.

Melatonin Studies
An inordinate list of studies from Medline. For the technically-minded.

Erowid Melatonin Vault : Info #1
Information about Melatonin from the Cognative Research Institute: Mental performance, Depression, Extending Lifespan, Stress, Cancer, Alzheimer's, Exposure to Electromagnetic Fields, Dosage, Precautions, Sources, References.

Melatonin - Miracle or Menace?
Dr. Josephine Arendt, an endocrinologist at the University of Surrey in southern England. says there is good evidence that taking synthesized melatonin tablets helps prevent jet lag and regulates sleep patterns in some people. Arendt, who said she tested the hormone on herself before using it on humans, said other claims were not borne out. ``I have personally taken it since 1981, and I have, in the process, become old, gray, wrinkled and fat,''

Claims for Melatonin Unproven - UC Davis (1997)
Eun-Kyu Lee, an assistant professor of clinical neurology at UC Davis Medical Center, has serious concerns about the safety of melatonin products. Consumers can never be sure about the quality of unregulated supplements, Lee says. She cites tryptophan tablets, a supplement that was popular and heavily marketed a few years ago. Impurities in some batches caused rheumatological and immunological complications,

Melatonin and Chronic Fatigue Syndrome
In another ground-breaking study doctors at Guy's and St. Thomas's hospitals have discovered a link between melatonin - a chemical which reinforces the immune system - and chronic fatigue syndrome .

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Melatonin Discussion 1  
Newsgroup Discussion: In the two years that I have spent researching the melatonin literature and interviewing 50+ researchers world-wide (in conjunction with my co-author Russel J. Reiter, Ph.D.) I have learned of a significant number of possible uses for melatonin.

Melatonin May Not Work  
Newsgroup Discussion: Melatonin may not effect your body clock since scientists are still unsure as to how the SCN (central pacemaker) influences circadian rhythms.

Melatonin and Tendonitis  
Newsgroup Discussion: I started taking Melatonin about a two months ago. Developed tendonitis (tennis elbow) in my left arm.

Melatonin Hangover  
Newsgroup Discussion: Melatonin makes me extremely tired. It also gives me a headache the next day.

Melatonin - and grogginess  
Newsgroup Discussion: I tried using melatonin. I found that it helped me sleep, but I also had problems with grogginess even with tiny doses.


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